ChemBK
  • Home
  • Product Category

L-Tyrosine, 3-hydroxy-.alpha.-methyl-

alpha-methyldopa

CAS: 555-30-6

Molecular Formula: C10H13NO4

  1. Home
  2. Product Category
  3. other
  4. other
  5. L-Tyrosine, 3-hydroxy-.alpha.-methyl-

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Names and Identifiers

Name alpha-methyldopa
Synonyms METHYLDOPA
alpha-methyldopa
(S)-(-)-alpha-Methyldopa
3-hydroxy-N-methyltyrosine
3-Hydroxy-α-methyl-L-tyrosine
3-Hydroxy-alpha-methyl-L-tyrosine
L-A-METHYL DOPA MK-351, METHYLDOPA
L-Tyrosine, 3-hydroxy-.alpha.-methyl-
2-METHYL-3-(3,4-DIHYDROXYPHENYL)ALANINE
3-(3,4-Dihydroxyphenyl)-α-methyl-L-alanine
(2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
CAS 555-30-6
EINECS 209-089-2
InChI InChI=1/C10H13NO4/c1-11-7(10(14)15)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,11-13H,4H2,1H3,(H,14,15)

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Physico-chemical Properties

Molecular FormulaC10H13NO4
Molar Mass211.22
Density1.2545 (rough estimate)
Melting Point≥300°C
Boling Point350.89°C (rough estimate)
Flash Point217.7°C
Water Solubility10g/L(temperature not stated)
Vapor Presure2.19E-08mmHg at 25°C
Appearancepowder to crystal
ColorWhite to Almost white
Merck14,6055
pKa2.28±0.26(Predicted)
Storage ConditionSealed in dry,2-8°C
Refractive Index-14 ° (C=1, H2O)
Physical and Chemical PropertiesSoluble in hot water, dilute acid and dilute alkali, slightly soluble in cold water and acetone and other organic solvents.
UseL-Methyldopa is a B- receptor blocking cardiovascular drug that has a good effect on moderate-procedure primary and renal hypertension.

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Risk and Safety

Safety DescriptionS24/25 - Avoid contact with skin and eyes.
WGK Germany3
RTECSYP2860000
FLUKA BRAND F CODES10-23
HS Code29181990
ToxicityLD50 oral in rabbit: 713mg/kg

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Standard

Authoritative Data Verified Data

This product is L-3-(3, 4-dihydroxyphenyl)-2-methylalanine sesquihydrate. Calculated as dried product, including C10H13NO4, not less than 98.0%.

Last Update：2024-01-02 23:10:35

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Trait

Authoritative Data Verified Data
  • This product is white or off-white crystalline powder; Odorless.
  • This product is slightly soluble in water, slightly soluble in ethanol, extremely slightly soluble in ether, and easily soluble in dilute hydrochloric acid.

specific rotation

take this product, precision weighing, add aluminum chloride solution (take aluminum chloride hexahydrate 65g, add water to 100ml, add activated carbon 0.5g, shake for 10 minutes, filter, the filtrate was dissolved and quantitatively diluted with 1% sodium hydroxide solution to adjust the pH value to 1.5) to make a solution containing 44mg per 1 ml, which was measured according to law (General rule 0621), and the specific rotation was from 251 ° to 30 °.

Last Update：2022-01-01 11:38:14

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Differential diagnosis

Authoritative Data Verified Data
  1. take this product, add 0.lmol/L hydrochloric acid solution is dissolved and diluted to prepare a solution containing about 0401 mg per lml, which is determined by ultraviolet-visible spectrophotometry (general rule) and has a maximum absorption at a wavelength of 280nm, the absorbance was about 0.48.
  2. Take 10 mg of this product, add 3 drops of ninhydrin test solution, and show dark purple after placing.
Last Update：2022-01-01 11:38:14

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Exam

Authoritative Data Verified Data

acidity

take this product l. Add 100ml of fresh boiling cold water and add 1 drop of Methyl red indicator solution, if it is red, add 0.1 ml of sodium hydroxide titration solution (0.5 mol/L), which should be yellow.

hydride

take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.028% of standard gasification sodium solution, it shall not be deeper ().

Related substances

take an appropriate amount of this product, add the mobile phase to dissolve and quantitatively dilute to prepare a solution containing about 1 mg per 1 ml as a test solution; Take an appropriate amount for precision measurement, A solution containing 5ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. According to the determination of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as filler; Acetonitrile-phosphate buffer solution (2g of potassium dihydrogen phosphate and lg of phosphoric acid were taken and dissolved in of water)(5:95) as mobile phase; The detection wavelength was 278nm. The number of theoretical plates is not less than 2000 calculated from the methyl dopa peak. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 8 times of the retention time of the main component peak. If the impurity peak is shown in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ) , the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.

loss on drying

take this product, dry to constant weight at 125°C, weight loss should be 10.0% ~ 13.0% (General 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Last Update：2022-01-01 11:38:15

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Content determination

Authoritative Data Verified Data

take this product about 0.15g, precision weighing, add glacial acetic acid dissolved in 20ml, add crystal violet indicator liquid 1 drop, with high gas acid titration solution (0.1 mol/L titration to solution blue-green, and the results of the titration with blank test correction. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 21.12mg of C10H13N04.

Last Update：2022-01-01 11:38:16

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Category

Authoritative Data Verified Data

antihypertensive drugs.

Last Update：2022-01-01 11:38:16

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:38:16

L-Tyrosine, 3-hydroxy-.alpha.-methyl- - Methyldopa Tablets

Authoritative Data Verified Data

This product contains methyl DOPA (C10H13N04) should be 95.0%-105.0% of the label.

trait

This product is sugar-coated tablets, White after removing the coating.

identification

  1. take an appropriate amount of fine powder of this product and add 0.1 mol/L hydrochloric acid solution is dissolved and diluted into a solution containing about 0401 mg of Methyldopa per 1 ml, filtered, and the filtrate is determined by UV-Vis spectrophotometry (general rule), there is an absorption maximum at a wavelength of 280nm.
  2. take an appropriate amount of fine powder of this product (about equivalent to methyldopa lOmg), add a few drops of ninhydrin test solution, and heat to develop a deep purple color.

examination

  • dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (9-100) as the dissolution medium, the speed is rpm, operate according to law, after 45 minutes, take the solution and filter, take the filtrate 2ml accurately, put it in a lOml measuring flask, dilute it to the scale with dissolution medium, shake it well, the absorbance was measured at a wavelength of 0401 mn according to UV-Vis spectrophotometry (general rule). In addition, an appropriate amount of Methyldopa reference substance was accurately weighed, dissolved and diluted with hydrochloric acid solution (9-1000) to prepare a solution containing about 0.04mg per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 20 tablets of this product, remove the coating, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to methyl dopa O.lg ), put it in a 100ml measuring flask, add an appropriate amount of 0.05mol/L sulfuric acid solution, shake to dissolve methyldopa, add 0.05mol/L sulfuric acid solution to the scale, shake well, filter, precisely take 5ml of continued filtrate, put it in a 100ml measuring flask, add ferrous citrate sulfate solution [Take lg of sodium pyrosulfite, add 200ml of water to dissolve, add lml of hydrochloric acid titration solution (lmol/L), ferrous sulfate 1.5g and sodium citrate 10G, mixed, obtained. This solution should be freshly prepared] 2ml mixed with amino acetate buffer solution (sodium bicarbonate 42g, potassium bicarbonate 50g and water 180ml); 37.5g of amino acetic acid and concentrated ammonia test solution 15ml were added with water to dissolve in 180ml. The two solutions were mixed, and water was added to 0401 ml)8ml, diluted to the scale with water, shaken, and the absorbance was measured by ultraviolet-visible spectrophotometry (general) at a wavelength of 550mn. In addition, take the methyldopa reference substance 0.lg accurately, put it in a 100ml measuring flask, add 0.05md/L sulfuric acid solution to dissolve and dilute to the scale, shake well, take 5ml accurately and put it in a 100ml measuring flask, according to the above method, from the "add ferrous sulfate citrate solution", the same method of determination, calculation, that is.

category

Same as methyldopa.

specification

10.25g (as C10H13NO4)

storage

light shielding, sealed storage.

Last Update：2022-01-01 11:38:17
L-Tyrosine, 3-hydroxy-.alpha.-methyl-
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Carbidopa Impurity 1（Carbidopa EP Impurity A） Visit Supplier Webpage Request for quotation
CAS: 555-30-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: alpha-methyldopa Request for quotation
CAS: 555-30-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Carbidopa Impurity 1（Carbidopa EP Impurity A） Visit Supplier Webpage Request for quotation
CAS: 555-30-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: alpha-methyldopa Request for quotation
CAS: 555-30-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
View History
L-Tyrosine, 3-hydroxy-.alpha.-methyl-
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001